Interesting genetic results from 23andme



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whirlingmind
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Sun Apr 21, 2013 8:37 am

All these are, I believe, predictions based on my genetic type and not written in stone, but I think it's interesting that these are similar to AS traits:

pain sensitivity = increased
measures of intelligence = lower non-verbal IQ
memory = increased episodic memory
avoidance of errors = much less efficient at learning to avoid errors

These are my personal risks based on my genetics:

Bipolar disorder (average risk 14%) 20%
Schizophrenia I have 2 markers, 1 of which is a high-risk marker
Tourettes syndrome, I have moderately higher risk because I have one marker, something to do with the SNP

I find this interesting because AS has a known genetic link to both bipolar and schizophrenia, and despite the fact that they can't yet do diagnostic genetic tests for autism, the same genetic parts may be what has shown up here.

Ettina has been really helpful listing for me known SNPs which can be causative for autism, so I now need to trawl through all those and try to link it up with my 23andme report.


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oceandrop
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Sun Apr 21, 2013 11:47 am

Diagnosed Asperger's, here's mine:

pain sensitivity = typical
measures of intelligence = Higher Non-Verbal IQ
memory = typical episodic memory
avoidance of errors = much less efficient at learning to avoid errors

Risks:

Bipolar disorder 0.10% vs average of 0.10% (0.94x average)
Schizophrenia typical
Tourettes syndrome typical



ezbzbfcg2
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Sun Apr 21, 2013 11:51 am

How much does a test like that cost? How long does the whole process take? What other things does it tell you?



whirlingmind
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Sun Apr 21, 2013 11:53 am

It's all on: www.23andme.com


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ezbzbfcg2
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Sun Apr 21, 2013 1:21 pm

whirlingmind wrote:
It's all on: www.23andme.com


So is it really on $99? Or are there additional fees?

The website gives an overview, not point-by-point.

But if I do get it done, I'll be sure to post all the accurate details rather than just direct someone to a website.



AgentPalpatine
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Sun Apr 21, 2013 1:24 pm

ezbzbfcg2 wrote:
whirlingmind wrote:
It's all on: www.23andme.com


So is it really on $99? Or are there additional fees?

The website gives an overview, not point-by-point.

But if I do get it done, I'll be sure to post all the accurate details rather than just direct someone to a website.


In all fairness, it would be easier to send someone to the website than to type out the entire explanation again.


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whirlingmind
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Sun Apr 21, 2013 1:33 pm

Exactly, some people want spoon feeding. :roll:

And yes, it really is "only" $99.


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DVCal
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Sun Apr 21, 2013 2:13 pm

Yes it is $99, and it is really great for other things too like ancestry.

There are 3rd party ancestry tools you can upload your SNP data too to get other perspective on your ancestry.

Mine is:

pain sensitivity = increased
measures of intelligence = Average non-verbal IQ
memory = increased episodic memory
avoidance of errors = much less efficient at learning to avoid errors

It is a really good bargain too at $99, it was $299 when I did it.



DVCal
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Sun Apr 21, 2013 2:51 pm

I am just curious but was their a big shipping fee to the UK?



Popsicle
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Sun Apr 21, 2013 2:52 pm

Wow - I didn't know that site got that specific. Interesting.

I didn't do 23andme because I did not want to get something horrible like "90 percent chance of (insert fatal disease here)" and then get bummed about that.

But those sound interesting. Then again I do wonder what is their purpose in telling people the odds of getting something they can't cure?? I mean really??

The other people in my family felt the same way so it didn't seem worth it to test at 23andme for us, because part of the fun is seeing just where family DNA overlaps.

I did genetic tests elsewhere and found out about family history and that was interesting too.

ETA: ez I didn't test there but when I had my testing done elsewhere it took a couple months or so to get results back and they sent them by email. What happens is you get a test kit in the mail. It has instructions. Some tests require a cheek swab, some require spit in their vial. Then you package it up according to instructions and mail it in their envelope. You have to pay the postage to mail it in. Different test places have differnt prices. Family Tree DNA often has sales, and has a huge database. National Geographic has a test that mostly looks at your ancestors entire migratory history. 23andme used to cost more but to increase their database (how many people are in it) they dropped their price to 99 dollars. 23andme tests autosomal DNA only, I think. Both males and females can use autosomal DNA kits. It's the "family finder" or "Cousin finder" test you might've seen on some genealogy shows. Other types of DNA depend on X or Y Chromosome. Men can do the Y DNA and mtDNA test and woman only mtDNA, both can do autosomal.

That's the short of it, hope that helped.



oceandrop
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Sun Apr 21, 2013 4:55 pm

Popsicle wrote:
But those sound interesting. Then again I do wonder what is their purpose in telling people the odds of getting something they can't cure?? I mean really??


When it comes to those it's-kind-of-a-big-deal tests, the website takes you through a couple of dialogs suggesting you can opt out, get a genetic counsellor before viewing the results, etc.

The website is really impressive overall. It even put me in touch with a lot of 2nd and 3rd cousins I didn't know existed!

The most useful part for me though is knowing my risks, for example I'm at considerably higher risk for type II diabetes and that makes me think twice before binging on sugary foods. I think it's an amazing bargain for $99 really.



jdbob
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Sun Apr 21, 2013 7:28 pm

I sent in my sample, probably another 5 or 6 weeks before I hear from them.



whirlingmind
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Sun Apr 21, 2013 7:56 pm

DVCal wrote:
I am just curious but was their a big shipping fee to the UK?


It was a little hefty, but I can't remember exactly how much, maybe £20-30 at a guess. I'd have to check my bank account to be sure exactly.


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whirlingmind
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Sun Apr 21, 2013 8:00 pm

What I've now done, is cross-checked my SNP genotypes against a list of those believed to cause more autism. There was a list of 73 and I had 19 genotypes in the "more autism" SNPs. My maths is crap but I think that's more than a third?

I have no idea what to measure this against. Does anyone else know what ratio of autistic genotypes would be low, medium or high? (I can PM the list Ettina sent me if necessary). I mean, it seems fairly high to me, but maybe every Joe Bloggs has 20-30 autistic genotypes in their SNPs and it's not.


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