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hypersensitivity to anti-depressants (SSRIs and tricyclics)

 
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bloodymary
Emu Egg
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Joined: Jun 19, 2007
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PostPosted: Tue Jun 19, 2007 2:21 pm    Post subject: hypersensitivity to anti-depressants (SSRIs and tricyclics) Reply with quote

Does anyone know if it's safe for an autistic person to use SSRIs (eg Prozac) and tricyclic anti-depressants (eg amitriptyline) together? I'd been taking a first generation antihistamine (or anti-allergy) medication called Pirition (or chlorpheniramine) for three weeks before I stopped. It has a similar mechanism to Prozac (and St John's Wort) and while it made me sleep continuously at first, towards the end i started getting agitated and unmotivated, and now I have insomnia. Such drugs are known to cause these symptoms if administered in too large a dosage. I've stopped for a week but I still feel depressed (that's how I would describe my symptoms anyway) and I've been thinking of going back to taking amitriptyline to help with my depression. However, I thought of taking the piriton at the same time to help relief anxiety. (SSRIs are supposed to help with anxiety, in certain people anyway). Does anyone have any idea if this is recommended? I'd ask a doctor but they're stupid and don't even know about the contraindications of the drugs they prescribe to normal people, much less someone who isn't neurotypical. Please help! Thanks!
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postpaleo
Huh?


Joined: Feb 22, 2007
Age: 58
Posts: 3044

PostPosted: Wed Jun 20, 2007 4:24 am    Post subject: Re: hypersensitivity to anti-depressants (SSRIs and tricycli Reply with quote

bloodymary wrote:
Does anyone know if it's safe for an autistic person to use SSRIs (eg Prozac) and tricyclic anti-depressants (eg amitriptyline) together? I'd been taking a first generation antihistamine (or anti-allergy) medication called Pirition (or chlorpheniramine) for three weeks before I stopped. It has a similar mechanism to Prozac (and St John's Wort) and while it made me sleep continuously at first, towards the end i started getting agitated and unmotivated, and now I have insomnia. Such drugs are known to cause these symptoms if administered in too large a dosage. I've stopped for a week but I still feel depressed (that's how I would describe my symptoms anyway) and I've been thinking of going back to taking amitriptyline to help with my depression. However, I thought of taking the piriton at the same time to help relief anxiety. (SSRIs are supposed to help with anxiety, in certain people anyway). Does anyone have any idea if this is recommended? I'd ask a doctor but they're stupid and don't even know about the contraindications of the drugs they prescribe to normal people, much less someone who isn't neurotypical. Please help! Thanks!


A couple of things. The net is no place, even here, to be asking exactly what you are. too much information you might be leaving out and not on purpose. too many self trained people that think they know something that is just plain out and out wrong or only half right. What I'm saying is, it's pretty easy to get the wrong info and think it's right on. Just the St Johns that you mentioned, you ever seen the read out on what that can mess with? And that stuff is over the counter. yes more then a few of us feel about like you do about the doctor world, but, there are some good ones and they do know what you can combine. Shop for a good doctor, it really could save you some serious grief. This med route can get nasty sometimes. That advice I can tell you from a personal stand point. But ultimatly we are the ones that need to convey to them what is going on with us, you do sound like you can do that pretty well. that's an advantage, there were points were i just couldn't get it out in the right way.
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Claradoon
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Joined: Aug 24, 2006
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PostPosted: Wed Jun 20, 2007 5:09 am    Post subject: Reply with quote

Did you stop cold? Coming off meds has to be supervised by a doctor, even if you only took it for 3 weeks. If you stopped the wrong way, that could be what's causing your problems now. That's what happened to me. I went to a clinic and they fixed it. I don't like docs much, but I really think this a situation where a doc is the one to see.
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ephemerella
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Joined: Mar 03, 2007
Posts: 163

PostPosted: Fri Jun 22, 2007 3:38 am    Post subject: Yes No and Yes Reply with quote

Yes, I have had many problems being too sensitive to SSRI's and now MAOI's. They have a bad effect on me.

I disagree with the individual who posted a reply that you shouldn't be investigating these questions. Doctors do very little to understand what they are giving you and how to tell if it's not workin out well. Even trained psychiatrists are a problem. I had a psychiatrist who specializes in psychopharmacology prescribe me one bad SSRI prescription after anohter.

Do what you need to do. No one else is going to know your functioning in as much level of detail as you will.

Annette
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simon2wright
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Joined: Feb 02, 2006
Posts: 62

PostPosted: Sun Jun 24, 2007 4:03 pm    Post subject: Reply with quote

I take amitriptyline with fluoxetine without any problems, but you have to be careful as the fluoxetine causes the amitriptyline levels to increase.
I am on a much lower dose than normal, only 10mg of fluoxetine and 25mg of amitriptyline, maybe because I am an aspie.
Also I sleep much better than I used to.
Simon
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Ticker
Come to the Dark Side; we have cookies...


Joined: Aug 26, 2006
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PostPosted: Mon Jun 25, 2007 5:31 am    Post subject: Reply with quote

Call your local hospital pharmacy and ask to speak to the head pharmacist. The hospitals often get the best pharmacists in town. Then ask him or her your med questions. They are usually very qualified to answer complicated interaction questions. Doctors cannot generally, but pharmacists can. Remember ask head pharmacist not a pharmacy technician.
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shadexiii
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Joined: Dec 16, 2006
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PostPosted: Mon Jun 25, 2007 11:51 am    Post subject: Reply with quote

I agree with both Claradoon and Ticker. Even if there is a problem with medication, it could create a bigger problem to immediately stop taking it. Talking with a pharmacist would probably be the best solution. A psychiatrist should be qualified, but at times I've gotten the feeling that they work in more of a trial and error way than a planned "method." It wouldn't be fair to say that all of them work in such a way, or that all of them aren't nearly as informed as they should be, I'm sure at least some of them are qualified and competent. At times the issue is simply finding the right one. I don't know if I ever did, psychologist or psychiatrist, and I just sort of gave up on it. Not sure if that was the best idea, and not one I would recommend to others, but it worked reasonably well for me.
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