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Shyness drug could boost confidence
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spudnik
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PostPosted: Wed Jun 25, 2008 3:41 pm    Post subject: Shyness drug could boost confidence Reply with quote

Scientists create a new drug that can help people overcome shyness and reduce anxiety.
http://www.telegraph.co.uk/news/worldnews/northamerica/usa/2175030/Shyness-drug-could-boost-confidence.html
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liloleme
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PostPosted: Wed Jun 25, 2008 3:51 pm    Post subject: Reply with quote

Hey thats a novel idea. The hormone is also released when you are breastfeeding...its a nice calming feeling. Its actually one of the reasons I breastfed my kids.
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Rainbow-Squirrel
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PostPosted: Wed Jun 25, 2008 5:16 pm    Post subject: Reply with quote

I don't know about this drug, but talking about drugs that can boost your confidence and make you more extroverted what happened to me last week is amazing (at least to me Wink). I was on the workplace, I was about to have a meltdown, I hated this job (see work burnout) the boss was in the room next to me, I just coudn't go on, so, out of desperation, I decided to take 10 mg of paroxetine (SSRI), the drug I have taken for 8 months I fotunately had with me. After an hour, all of a sudden, I felt confident, walked out of my room and to the boss and told him what I was thinking for months but I just hadn't the corauge to say. On monday I left the job.
I will definitely stay on my 10 mg of paroxetine, without I'm just too weak.
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LeKiwi
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PostPosted: Wed Jun 25, 2008 5:36 pm    Post subject: Reply with quote

Oh goodie, another drug to cure the human condition. Rolling Eyes
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liloleme
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PostPosted: Wed Jun 25, 2008 5:42 pm    Post subject: Reply with quote

I think calling it a drug would be a bit harsh. It would be a synthetic hormone.
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Everchanging
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PostPosted: Wed Jun 25, 2008 6:15 pm    Post subject: Reply with quote

How long before this one causes a high school massacre?
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Last edited by Everchanging on Fri Jun 27, 2008 9:38 am; edited 1 time in total
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CRACK
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PostPosted: Wed Jun 25, 2008 6:32 pm    Post subject: Reply with quote

Hey, I wouldn't mind trying this for experimental purposes.
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youknowandy
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PostPosted: Thu Jun 26, 2008 2:03 am    Post subject: Reply with quote

I've thought at times that if I ever wanted to be able to handle the stresses of a "full life" (job + wife + kids), that I would need to take some kind of drug...
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TheBladeRoden
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PostPosted: Thu Jun 26, 2008 3:34 am    Post subject: Reply with quote

Hell, I'd try it if it's safer than alcohol (which I've been using until now as my social crutch)
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LTP
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PostPosted: Thu Jun 26, 2008 3:37 am    Post subject: Reply with quote

Rainbow-Squirrel wrote:
I don't know about this drug, but talking about drugs that can boost your confidence and make you more extroverted what happened to me last week is amazing (at least to me Wink). I was on the workplace, I was about to have a meltdown, I hated this job (see work burnout) the boss was in the room next to me, I just coudn't go on, so, out of desperation, I decided to take 10 mg of paroxetine (SSRI), the drug I have taken for 8 months I fotunately had with me. After an hour, all of a sudden, I felt confident, walked out of my room and to the boss and told him what I was thinking for months but I just hadn't the corauge to say. On monday I left the job.
I will definitely stay on my 10 mg of paroxetine, without I'm just too weak.


Thats the placebo effect not an SSRI at work. SSRI's take weeks to start working and even then their benefits are not nearly as pronounced. In fact I don't think they have documented any changes in confidence because of paroxetine. Anxiety relief and depression yes-confidence not so much. Ah never mind I missed the part where mentioned you were on it for months. But even then it would take more then an hour to cause what you described. SSRI's do not cause spiky chemical changes. They gradually raise the amount of serotonin your neurons bath in and try to keep those levels steady. Individual dosages can be seen as maintenance.
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Rainbow-Squirrel
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PostPosted: Thu Jun 26, 2008 5:57 am    Post subject: Reply with quote

LTP wrote:
Thats the placebo effect not an SSRI at work. SSRI's take weeks to start working and even then their benefits are not nearly as pronounced. In fact I don't think they have documented any changes in confidence because of paroxetine. Anxiety relief and depression yes-confidence not so much. Ah never mind I missed the part where mentioned you were on it for months. But even then it would take more then an hour to cause what you described. SSRI's do not cause spiky chemical changes. They gradually raise the amount of serotonin your neurons bath in and try to keep those levels steady. Individual dosages can be seen as maintenance.


Reality just happens to be different.
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monty
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PostPosted: Thu Jun 26, 2008 8:32 am    Post subject: Reply with quote

LTP wrote:

Thats the placebo effect not an SSRI at work. SSRI's take weeks to start working and even then their benefits are not nearly as pronounced. In fact I don't think they have documented any changes in confidence because of paroxetine. Anxiety relief and depression yes-confidence not so much. Ah never mind I missed the part where mentioned you were on it for months. But even then it would take more then an hour to cause what you described. SSRI's do not cause spiky chemical changes. They gradually raise the amount of serotonin your neurons bath in and try to keep those levels steady. Individual dosages can be seen as maintenance.


To properly treat depression, it does take weeks. But SSRIs can have immediate effects. Consider these studies:

"Acute 5-HT Reuptake Blockade Potentiates Human Amygdala Reactivity."
"Do selective serotonin reuptake inhibitors acutely increase frontal cortex levels of serotonin?" (hint:yes)
"Effect of single-dose sertraline on the hypothalamus-pituitary-adrenal system, autonomic nervous system, and platelet function."

"... acute treatment with the SSRIs fluoxetine and paroxetine immediately causes increased serotonin levels"
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monty
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PostPosted: Thu Jun 26, 2008 8:36 am    Post subject: Reply with quote

Motherwort (herba Leonurus) is a plant that seems to affect the oxytocin receptors. It is calming, can normalize some types of irregular heartbeats, and (like oxytocin) stimulates uterine contractions in women.

http://en.wikipedia.org/wiki/Motherwort

PubMed studies: Leonuris and oxtyocin
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Rainbow-Squirrel
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PostPosted: Thu Jun 26, 2008 8:51 am    Post subject: Reply with quote

monty wrote:

To properly treat depression, it does take weeks. But SSRIs can have immediate effects. Consider these studies:

"Acute 5-HT Reuptake Blockade Potentiates Human Amygdala Reactivity."
"Do selective serotonin reuptake inhibitors acutely increase frontal cortex levels of serotonin?" (hint:yes)
"Effect of single-dose sertraline on the hypothalamus-pituitary-adrenal system, autonomic nervous system, and platelet function."

"... acute treatment with the SSRIs fluoxetine and paroxetine immediately causes increased serotonin levels"


Thanks for the detailed support Monty. Wink

In particular I can totally relate to the second line. 30-40 minutes after taking the (half) pill (I wasn't currently taking it on a regular basis) I felt something was happening in my frontal cortex, something very strong, an increased activity and a resulting sense of personal strength.
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LeKiwi
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PostPosted: Thu Jun 26, 2008 1:33 pm    Post subject: Reply with quote

liloleme wrote:
I think calling it a drug would be a bit harsh. It would be a synthetic hormone.


....a drug. And think of the other synthetic hormones out and about, i.e. the contraceptive pill or HRT for the menopause, and the huge side effects they both have and major links to cancer and infertility? Just because it's an analogue of something natural does NOT make it safe by any stretch of the imagination.
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