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Mikomi
Phoenix
Joined: Jan 25, 2008
Posts: 781
Location: On top of your TV, lookin' at you funny.
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 Posted: Tue Jan 29, 2008 1:13 am Post subject: Who Has Autoimmune Disease? |
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Since reading that autism and immune dysfunction might be related, I'm quite curious.
Here's a rough list.
http://immunedisorders.homestead.com/auto_immune_list.html
There are some missing. Chime in of course if yours isn't there. |
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Pithlet
Deinonychus
Joined: Jan 20, 2008
Age: 26
Posts: 363
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| Posted: Tue Jan 29, 2008 1:41 am Post subject: |
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| Havn't been diagnosed with it, but I'm always getting sick. At least more often and for longer periods than most people. I'm also always getting infections, and I'm pretty sure I had Chicken Pox twice when I was a kid. |
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zendell
Free Thinker
Joined: Nov 11, 2007
Posts: 1174
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| Posted: Tue Jan 29, 2008 1:59 am Post subject: |
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Some people think autism should be classified as an autoimmune disorder. Most autistics have autoimmunity in the form of antibodies that attack the brain (anti-MBP autoantibodies). These autoantibodies that attack the brain also occur in other neurological disorders.
Information about MBP autoantibodies
| Quote: | MBP autoantibody titers are highly correlated to exacerbation and relapse in MS. MBP autoantibodies are also found in up to 64% of HIV-associated neurological syndrome, 58% of autistic children, 30% of Japanese encephalitis and 30% of subacute sclerosing panencephalitis (SSPE) patients.
http://www.specialtylabs.com/tests/details.asp?id=1056 |
Autoimmunity in autism
58% of autistics have myelin basic protein (MBP) autoantibodies
Where do these autoantibodies come from?
60% of autistics have an unusual MMR antibody, of these 90% have anti-MBP autoantibodies
90% of autistics with measles antibodies (from vaccine) have anti-MBP autoantibodies
84% of autistics with human herpes virus 6 antibodies have anti-MBP autoantibodies
83% of autistics have autoantibodies against casein (protein found in milk)
50% of autistics have autoantibodies against gluten (protein found in wheat)
I think it's interesting that anti-MBP autoantibodies are associated with measles in autism because these autoantibodies are also associated with subacute sclerosing panencephalitis (SSPE) which is a brain disorder caused by infection with a mutant measles virus. The measles virus in SSPE causes inflammation in the brain that causes the brain to swell. Some studies find inflammation and larger brains in autistics.
| Quote: | Brain Behav Immun. 1993 Mar;7(1):97-103.
Antibodies to myelin basic protein in children with autistic behavior.
Singh VK, Warren RP, Odell JD, Warren WL, Cole P.
Biomedical Division, Center for Persons with Disabilities, Logan, Utah.
Based on a possible pathological relationship of autoimmunity to autism, antibodies reactive with myelin basic protein (anti-MBP) were investigated in the sera of autistic children. Using a screening serum dilution of 1:400 in the protein-immunoblotting technique, approximately 58% (19 of 33) sera of autistic children (< or = 10 years of age) were found to be positive for anti-MBP. This result in autistics was significantly (p < or = .0001) different from the controls (8 of 88 or only 9% positive), which included age-matched children with normal health, idiopathic mental retardation (MR) and Down syndrome (DS), and normal adults of 20 to 40 years of age. Since autism is a syndrome of unknown etiology, it is possible that anti-MBP antibodies are associated with the development of autistic behavior.
PMID: 7682457 [PubMed - indexed for MEDLINE] |
| Quote: | ELISA analysis showed a significant increase in the level of MMR antibodies in autistic children. Immunoblotting analysis revealed the presence of an unusual MMR antibody in 75 of 125 (60%) autistic sera but not in control sera...Furthermore, over 90% of MMR antibody-positive autistic sera were also positive for MBP autoantibodies, suggesting a strong association between MMR and CNS autoimmunity in autism. Stemming from this evidence, we suggest that an inappropriate antibody response to MMR, specifically the measles component thereof, might be related to pathogenesis of autism.
http://www.ncbi.nlm.nih.gov/pubmed/12145534 |
| Quote: | Clin Immunol Immunopathol. 1998 Oct;89(1):105-8.
Serological association of measles virus and human herpesvirus-6 with brain autoantibodies in autism.
Singh VK, Lin SX, Yang VC.
College of Pharmacy, University of Michigan, Ann Arbor, Michigan, 48109-1065, USA.
Considering an autoimmunity and autism connection, brain autoantibodies to myelin basic protein (anti-MBP) and neuron-axon filament protein (anti-NAFP) have been found in autistic children. In this current study, we examined associations between virus serology and autoantibody by simultaneous analysis of measles virus antibody (measles-IgG), human herpesvirus-6 antibody (HHV-6-IgG), anti-MBP, and anti-NAFP. We found that measles-IgG and HHV-6-IgG titers were moderately higher in autistic children but they did not significantly differ from normal controls. Moreover, we found that a vast majority of virus serology-positive autistic sera was also positive for brain autoantibody: (i) 90% of measles-IgG-positive autistic sera was also positive for anti-MBP; (ii) 73% of measles-IgG-positive autistic sera was also positive for anti-NAFP; (iii) 84% of HHV-6-IgG-positive autistic sera was also positive for anti-MBP; and (iv) 72% of HHV-6-IgG-positive autistic sera was also positive for anti-NAFP. This study is the first to report an association between virus serology and brain autoantibody in autism; it supports the hypothesis that a virus-induced autoimmune response may play a causal role in autism. Copyright 1998 Academic Press.
http://www.ncbi.nlm.nih.gov/pubmed/9756729 |
| Quote: | Results revealed high seropositivity for autoantibodies to casein and gluten: 83.3% and 50% respectively in autistic children as compared to 10% and 6.7% positivity in the control group.
http://www.ncbi.nlm.nih.gov/pubmed/17974154 |
Other Immunological findings in autism - http://www.ncbi.nlm.nih.gov/sites/entrez |
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Aelith
Emu Egg
Joined: Jan 28, 2008
Posts: 8
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| Posted: Tue Jan 29, 2008 8:28 am Post subject: |
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| I have rheumatoid arthritis. I was diagnosed almost 4 years ago. |
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logitechdog
Phoenix
Joined: Nov 20, 2006
Age: 24
Posts: 970
Location: Uk - Thornaby
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| Posted: Tue Jan 29, 2008 9:04 am Post subject: |
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well when the nerovirus was here I did not get sick, but my mother & boyfriend did, so I guess my one is working, ermmm roar onions
http://autoimmunedisease.suite101.com/blog.cfm/bioflavinoids_in_autoimmune_disease
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Prior To Understanding What The Problems Are, An Individual Can Head In Many Different Directions, Wasting Valuable Time & Effort. When S’He Learns What The Problems Are & What Can Be Done Then S’He Has a “Compass” To Guide Him/Her |
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someguy
Blue Jay
Joined: Dec 17, 2007
Age: 34
Posts: 77
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| Posted: Tue Jan 29, 2008 9:13 am Post subject: |
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| Count me in for one who has something on that list. |
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Glencannon
Raven
Joined: Jan 23, 2008
Age: 28
Posts: 116
Location: Missoula, MT
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| Posted: Tue Jan 29, 2008 10:46 am Post subject: |
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| I have always had a great constitution, I never get sick. The worst I get is the occasional cold, stuffy nose and cough ect, but usually only once a year. I haven't missed a day at work due to illness ever (unless you count hangovers). I have no known allergies. Everyone in my family is the same way as me, from my immediate family to my extended family, both on my mothers side and my fathers side, hardy constitutions all around. |
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lovesusagi
Tufted Titmouse
Joined: Dec 20, 2007
Posts: 40
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| Posted: Tue Jan 29, 2008 10:56 am Post subject: |
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| i have severe latex allergy ! dont know if its related to my AS tho ....... |
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Ticker
Come to the Dark Side; we have cookies...
Joined: Aug 26, 2006
Posts: 2346
Location: Cage Free at the moment
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| Posted: Tue Jan 29, 2008 11:45 am Post subject: |
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Some of you that are posting do not even know what autoimmunity means. It has nothing to do with latex allergy, getting chicken pox or the cold.
I have an autoimmune illness called Crest Syndrome.
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I'm sweet on the outside and rotten within... |
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Mikomi
Phoenix
Joined: Jan 25, 2008
Posts: 781
Location: On top of your TV, lookin' at you funny.
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| Posted: Tue Jan 29, 2008 11:51 am Post subject: |
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| zendell: very interesting info, I'm going to read more on those. |
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Sophist
Professor of Pedantry
Joined: Apr 24, 2005
Posts: 6170
Location: St. Louie
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| Posted: Tue Jan 29, 2008 12:15 pm Post subject: |
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I suspect myself of having an IgA Deficiency and a mild gluten allergy; however, I can't be for certain since I don't have insurance. 
But my symptom history fits IgAD perfectly as well as my current health status. And IgAD and Celiac's frequently go hand in hand.
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GESTALT: An Autism and Psychology Discussion Forum
http://asdgestalt.com
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Beenthere
10 Miles South of Sanity
Joined: Dec 30, 2005
Age: 41
Posts: 2082
Location: Pa.
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| Posted: Tue Jan 29, 2008 12:21 pm Post subject: |
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Fibro, CFS, & Raynauds.
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*Normal* is just a setting on the dryer. |
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logitechdog
Phoenix
Joined: Nov 20, 2006
Age: 24
Posts: 970
Location: Uk - Thornaby
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| Posted: Tue Jan 29, 2008 8:29 pm Post subject: |
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| Ticker wrote: | Some of you that are posting do not even know what autoimmunity means. It has nothing to do with latex allergy, getting chicken pox or the cold.
I have an autoimmune illness called Crest Syndrome. |
Autoimmune diseases are illnesses which occur when the body's tissues are attacked by its own immune system. The result is activation of the immune system causing injury to tissues that result in injury similar to scar tissue formation. Additionally, medications are used to suppress the overly active immune system.
a bacteria or virus triggers an immune response, and the antibodies or T-cells attack normal cells because they have some part of their structure that resembles a part of the infecting germ.
or it can be genetic.....
_________________
Prior To Understanding What The Problems Are, An Individual Can Head In Many Different Directions, Wasting Valuable Time & Effort. When S’He Learns What The Problems Are & What Can Be Done Then S’He Has a “Compass” To Guide Him/Her |
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beau99
B.S. Detector
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Joined: Nov 06, 2007
Age: 22
Posts: 1302
Location: A cruel H*llhole called Earth.
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| Posted: Tue Jan 29, 2008 8:42 pm Post subject: |
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No autoimmune issues that I'm aware of...
_________________
My site: Thoughts of an Autistic (updated May 20, 2008)
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hypermorphic
Tufted Titmouse
Joined: Dec 26, 2007
Age: 31
Posts: 41
Location: Denver, CO
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| Posted: Tue Jan 29, 2008 9:36 pm Post subject: |
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Grave's is the only one I've confirmed with a lab test, but they run in the family on my mom's side. I can't eat wheat or milk, but I haven't gone for a celiac test yet due to lack of health insurance.
I'm not sure about other aspies with AI diseases, but eating wheat flares up my Grave's symptoms, so is there any suggestion that this might be a cause of "brain fog"? I'm having trouble finding info on anti-MBP antibodies, but wouldn't this also imply that AS could go into remission, or eventually cause severe neurological issues beyond the associated social problems? |
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