Unable to delete a registry entry.

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Windows registry editor wont let me delete a malicious registry entry (spyware). Spybot discovers it but is also unable to delete it. What do i do next? I have also tried running Malware bytes but it is unable to even make the discovery.

Are you sure it isn't a false positive by SpyBot? Windows may be stopping you from destroying your system by deleting an important and legitimate registry entry. I suggest running another (different) spyware / malware scanning tool before going any further.

That sounds like a good idea! I have had false positives from my old spyware program.