If I took an antibiotic, and probiotic, at the same time

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Whenever I've been on antibiotics, the doctor has usually told me to eat Yoghurt or cultured milk

I was on Doxycycline a few months ago for a sinus infection. My biggest issue is that after ten days I started gaining weight quickly.

It turns out that Doxycycline is sometimes prescribed to people to help them gain weight.

It ended up leveling out at about 10 pounds more than before I took it.

A New Antibiotic Weakness—Drugs Themselves Help Bacteria Survive

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Antibiotics save lives, but they are not fail-safe. Even when microbes haven’t acquired drug-evading genetic mutations—a hallmark of antibiotic resistance—the medications don’t always clear infections. A new study identifies a surprising reason why: At infection sites, antibiotics change the natural mixture of chemicals made by the body in ways that protect infecting bacteria. They also thwart the ability of the host’s immune cells to fight off the intruders.

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Collins and his colleagues at MIT’s Broad Institute, Harvard University and the University of California, San Diego, infected mice with Escherichia coli bacteria and gave some of them antibiotics. The scientists then took tissue samples from the mice and analyzed levels of certain bodily chemicals—known as metabolites—that bacteria can use to grow and multiply. At the sites of their infections, mice fed antibiotics had higher levels of some metabolites when compared with drug-free mice. The levels were also higher than what scientists detected in healthy mice.

To see if the metabolites changed antibiotic effectiveness, Collins and his colleagues added these isolated chemicals to E. coli grown in lab plates. They found that they needed to add higher drug concentrations to kill the bacteria when some of the chemicals were present. In other words, the chemicals that had been ramped up in the infected, antibiotic-treated animals were, ironically, making bacteria less susceptible to the drugs.

These chemical changes were incited not by bacterial cells, but by the animals’ own cells. The researchers learned this after giving antibiotics to so-called “germ-free” mice that had no bacteria and saw the same chemical changes. “It really is surprising,” says Eric Brown, the Canada Research Chair in Microbial Chemical Biology at McMaster University in Ontario, who was not involved in the research. “Antibiotics are supposed to be ‘magic bullets’ directed at bacteria but not at the person suffering from infection. Well, this work suggests that there is more going on, on the host side of things, than we might have thought.”