SSRI's in pregnancy may significantly Increase AS risk

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Edenthiel
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14 Dec 2015, 10:20 pm

Newsweek summary of study results
Link to actual summary of study

" new research suggests taking one popular class of the drugs—selective serotonin reuptake inhibitors (SSRIs)—during pregnancy can significantly increase a child’s risk for autism."

I find another serotonin link to be interesting...


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Misslizard
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15 Dec 2015, 10:44 am

Edenthiel wrote:
Newsweek summary of study results
Link to actual summary of study

" new research suggests taking one popular class of the drugs—selective serotonin reuptake inhibitors (SSRIs)—during pregnancy can significantly increase a child’s risk for autism."

I find another serotonin link to be interesting...

It's certainly possible.
It's best to avoid any drugs when pregnant.But if you have a depressed mom that's unmedicated there's also a risk that she will self medicate with other drugs or alcohol.They would be less likely to eat good or get prenatal care.
It's sort of a dammed if you do,dammed if you don't situation.


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Fnord
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15 Dec 2015, 10:49 am

Quote:
Conclusions and Relevance: Use of antidepressants, specifically selective serotonin reuptake inhibitors, during the second and/or third trimester increases the risk of ASD in children, even after considering maternal depression. Further research is needed to specifically assess the risk of ASD associated with antidepressant types and dosages during pregnancy.
The study does not address the risk of ASD associated with (a) something other than antidepressants, and (b) incidents where the mother took no drugs at all during pregnancy.


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BuyerBeware
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15 Dec 2015, 1:58 pm

I'm not going to lose any sleep over it.

Considering how bad off I was when I was carrying Ab (no, I didn't mean to get pregnant, but contraceptives fail, and better autistic than aborted), I shudder to think what could have happened to ALL of us (her, me, my hubby, and our other 3 kids) if flattening of affect associated with Prozac hadn't been keeping me on something at least externally resembling an even keel.

Now, I'm sick to the death of people passing out SSRI's for every unpleasant emotion. Pretending that, other than having to fake orgasms for the duration, there's no downside. BS. My MIL's attitude ("Feeling down?? Up your dose and smile!! !") makes me want to puke. Downright dystopian.

But... No, I don't think I'm going to guilt myself too much if that fluoxetine tipped the scales on Ab getting The Curse.

But, then, to be fair, I realized when I chose to have kids at all that there was a pretty good chance of one of them winding up with autism. So, ya know...


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Edenthiel
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15 Dec 2015, 7:05 pm

BuyerBeware wrote:
I'm not going to lose any sleep over it.

Considering how bad off I was when I was carrying Ab (no, I didn't mean to get pregnant, but contraceptives fail, and better autistic than aborted), I shudder to think what could have happened to ALL of us (her, me, my hubby, and our other 3 kids) if flattening of affect associated with Prozac hadn't been keeping me on something at least externally resembling an even keel.

Now, I'm sick to the death of people passing out SSRI's for every unpleasant emotion. Pretending that, other than having to fake orgasms for the duration, there's no downside. BS. My MIL's attitude ("Feeling down?? Up your dose and smile!! !") makes me want to puke. Downright dystopian.

But... No, I don't think I'm going to guilt myself too much if that fluoxetine tipped the scales on Ab getting The Curse.

But, then, to be fair, I realized when I chose to have kids at all that there was a pretty good chance of one of them winding up with autism. So, ya know...


Your last statement I think carries far more truth than anything else in the entire discussion, including the article in my original post. There are so, so many variables that go into the development of a fetus, including minute quantities of so many different hormones whose specific timing even has a huge effect on how the brain & other systems develop. Something the study did not reveal was whether the reason the children were more likely to be on the spectrum was due to the mother needing SSRI's because the gametes came from genetic lines that increase the chance of autism *and* the need for SSRI's, or due to some specific chemical interaction of the drug itself with the mother or baby's endocrine system. But to avoid SSRI's when needed to avoid the chance of autism in many cases would itself result in a miscarriage due to things like sky high cortisol levels.


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15 Dec 2015, 7:47 pm

So... This might also just mean that the risk for autism in children is higher if the mother is depressed, diagnosed or undiagnosed, and we know that autism and depression correlate, so.... Is it possible, that depressed autistic mothers have autistic babies?

I only read what's in this thread, not the abstract of the study, let alone the study.
Just looking for a place to apply some somewhat bayesian thinking.


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Edenthiel
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16 Dec 2015, 2:24 am

shlaifu wrote:
So... This might also just mean that the risk for autism in children is higher if the mother is depressed, diagnosed or undiagnosed, and we know that autism and depression correlate, so.... Is it possible, that depressed autistic mothers have autistic babies?

I only read what's in this thread, not the abstract of the study, let alone the study.
Just looking for a place to apply some somewhat bayesian thinking.

Or that mothers who have both autism and depression in their family tree are more likely to have an autistic child? But in either case, we're still just correlating symptoms. Is the mother depressed because her serotonin regulation is wonky because of genetics/epigenetics? And if so, perhaps if that's passed on *and* just the right other conditions and genes are present & expressing, the child is more likely to develop an autistic spectrum brain...


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16 Dec 2015, 12:40 pm

My reaction to this story when I heard it on TV was, all obstetricians will try to keep you away from all meds unless you really, really must have them. So either these mothers were so severely impaired that taking SSRIs was the lesser of two evils; or, they didn't get much in the way of prenatal care.

Do you see how this might skew the results?

We really can't tell from this study whether SSRIs had ANY effect on the babies.


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