Yes, the pedals are located exactly where you would expect. The gear-shift lever, however, is going to be convenient for your right hand, not your left, so you might want to consider driving an automatic-transmission car (lest you inadvertently attempt to shift gears on your car window...). I would also advise driving a gasoline (petrol) car, as the price of diesel fuel is markedly higher in most of the US.
Turn indicators and wiper controls, as noted above, vary from car to car; generally, the turn indicator lever is on the left side of the steering column, and the wiper controls on the right, but not always.
Another thing to keep in mind, and one which sometimes escapes our European friends, is the sheer scope of this country. Keep in mind that a trip from New York to Los Angeles is going to cover something over three thousand miles (almost 5000 km); the drive can be expected to take three to four days, exclusive of meals and rest breaks. And once you've gotten into the territory east of the Missouri River, keep an eye on your fuel gauge; once it gets below about a quarter of a tank, start looking for a gas station or truck stop, because in the western regions, it can be quite a piece between them, and you don't want to run out of fuel somewhere in the Sand Hills region of Nebraska, or the middle Utah, or God forbid the deserts of eastern California...
On a more practical note, if you purchase any fruit for snacking on while driving across the country, dispose of it before reaching California. The state's biggest industry is farming, and a fair bit of that is fruit; they're understandably a bit paranoid about the possibility of crop diseases or parasites being accidentally introduced. (Remember that the medfly invasion, which very nearly brought orange and lemon production in the state to a dead halt back in the '80s, happened when somebody bought some fruit in the Mediterranean region while on vacation, brought it home with them, and threw out fruit that had gone bad - and happened to contain Mediterranean fruit fly larvae...)
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Sodium is a metal that reacts explosively when exposed to water. Chlorine is a gas that'll kill you dead in moments. Together they make my fries taste good.