Lithium is still the most effective anti-manic agent, but it is NOT "mild." As LookingLost said, patients on lithium need regular blood tests to monitor for possible lithium toxicity. Too much is especially bad for the kidneys. But that doesn't mean that it isn't a highly useful medication. Unfortunately, lithium use has declined in recent years, due to the increased use of atypical anti-psychotics. People are starting to be more scared of lithium blood tests when they don't realize that the atypical anti-psychotics can be just as dangerous.
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Helinger: Now, what do you see, John?
Nash: Recognition...
Helinger: Well, try seeing accomplishment!
Nash: Is there a difference?