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qbit
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06 Feb 2007, 10:13 pm

I have heard of drugs that mask Asperger symptoms. Is there any drug that can do the opposite, e.g make an NT behave like an aspie, or make an aspie behave farther along the spectrum?



Mnemosyne
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06 Feb 2007, 10:26 pm

There aren't any drugs that "mask Asperger's symptoms." There are drugs that can help with one or two symptoms, if you have those symptoms. That is, there are anxiety drugs, if you have anxiety, but there aren't any drugs that improve social skills or stop you from having obsessive interests.



earthdweller
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06 Feb 2007, 11:05 pm

Hmmm.. To put it this way (I don't have a simple answer) --> The target of drugs made for the cns(i.e brain) in the cns is either the receptors or the enzymes that break down the neurotransmitters etc.. There are other pathways in the neurons also: the sodium and calcium channels(note: calcium channels can be a toxic source of free-radicals) {I think that most glutamate neuronal receptors rely on calcium in the excitory response to the activation of those receptos}

According to me, aspergers is less to do with recptors and more to do with how the connections are made. Also, according to me, the other stuff like adhd and schizophrenia are really just intact social brain connections as that is relates to a NT brain personality charactoristic... I think that this means that most NT's have more of a weak psyche as for that relates to its animalistic "conditionalist" psychology(or "conditionalism" or whatever its called) & (relates to the condtioned response-ring bell-food association-salivate reaction paradigm in vertabra animals) [This is also a philosophy by the way!]. This may be way they are more prone to rely on "getting high" without stopping to consider anything else etc..

this relates to speculation:

:arrow: Anyway, the symptoms that are a target to alter in people can be stuff like "the arousal system" [i.e GABA / depressants] (this relates to stuff like sensitivities to noise / other things that can cause anxiety etc), personality / reward and punishment drives (serotonin Noroepinephrine etc), and then impulse and instinctual drives (dopamine blocking agents ["schizophrenia" symptoms] or stimulants used for adhd [dopamine enhancers]). So to define aspi qaulities would be more like a heighthened arousal system (+ low endorphins)... :wink:

this may be considered:

:arrow: I couldn't think of a single chemical or whatever, however, there may be technological stuff that can stimulate different parts of the brain. This could be something like the megnetic stimulation thing or something like external DC brain wave amplification(used on the scalp). Side effects of altering brain waves etc are in the catagory of things like seizures or abnormal neurotransmitter depletion.

:arrow: Other than that, dopamine upregulation & also stimulation of dopamine receptors can lead to obsessive compulsive behaviors which seems to be a bit aspyish(can lead to psychosis). Other than that, enhancing acetecholine(if I could spell it right) may also relate to some associated charactoristics that could be part of aspergers since it is responsible for the formation of memories but it does among other things just as different receptors of the same neurotransmitter type carry out different functions. So it may be more of a recptor thing rather than a chemical that is responsible for certain behaviors.



earthdweller
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07 Feb 2007, 12:07 am

Before I forget:

An amphetamine is a stimulant if anyone needs a reminder. The effect that certain amphetamines can have are increased energy and motivation... But this can cause symptoms of psychotic behavior / mania. These symptoms need time to progress and develope. Other stimulants that are considered weak but activate dopamine and serotonin etc are aderall and ritalin etc. These chemical somehow work (mask symptoms) in people with ADHD as a calming effect. This also can cause obsessive compulsive and self-preserved like behaviors over time(if this was like aspergers lol). But this is depending on the person.

An amphetamine is something that releases dopamine. Other stuff such cocaine only activates the receptors for dopamine + serotonin.

Caffeine is also in the catagory as a stimulant. It is classified as a very weak stimulant (The lethal dosage is 10grams). We only consume 100 to 200 mg from coffee + less with moderate drinking pop(20mg to 45mg). But not the same stimulant catagory as stuff like amphetamines etc.. Caffeine and other related compounds stimulates the brain as they are a stimulant. In people who are significantly affected by the stimulant properties, it can significantly raise blood-pressure and contribute to increase heart rate. However, these compounds to do not cause severe imbalances in the dopamine system as amphetamines. So I think that.. if aspergers was like being more stimulated then caffeine can also cause this effect. (its stimulant properties are linked to its activation on certain parts of the brains' arousal system)

The catagory I beleive that these compounds is in is called a "Xanthene". The molecules that activate these receptors in the arousal system look similar like a molecule called "ATP". This is interesting because "ATP" is a break down product made by the mitochondria. So I think that if mitochondria were all related more or less like ours than that is a universal concept in cellular metabolism.