I can do great with 1 interlocuter. "Hey, you're not autistic!" is a common refrain. I do seem to have problems with 2 or more, however. Shortly after graduating college back in 2008, at a time when I thought my autism/Aspeger's was something I had completely left behind, I went to a job interview which had 2 interviewers! At the end, one of the interviewers said that I stared too much when I spoke. I had no idea.
At work, when in a conversation with multiple people, I do notice that I have difficulty getting my point in. I wait for the other person to stop, and then I hear the person stop, but then when I begin to speak someone else has already begun.
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"You have a responsibility to consider all sides of a problem and a responsibility to make a judgment and a responsibility to care for all involved." --Ian Danskin