phosphatidy serine??? advice please

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i wrote in before for advice my little girls anxiety levels are through the roof sometimes, someone adviced herbal medicines kalms ,weve been trying them for a while , not much change . we cant seem to find what triggers them ,it can be a whole day ,week,she gets near hysterical ,she says no understands or cares how stressed she feels,its very distressing as parent to feel so helpless. she wont let us comfort her she just runs around the house like a headless chicken,crying ,holding her head,being abusive to any one who trys to help weve tried everything, all proffesional advice,cognitive therapy ,yoga ,massage,distraction , some one suggested on my last post medication called phosphatidy serine ?? were can i get it , does it help, are ther any side affects my daughter is 10 she has high functioning aspergers . does anxiety levels get higher during puberty , and will it get easier for her as she gets older.

Hi, I'm not the one who suggested "phosphatidy serine", but I am thinking that is a misspelling OR it is something similar to what I am taking. I have Aspergers and Brain Damage of the frontal and right lobes. Someone with brain damage told me Phosphatidyl Choline would help. I noticed my functionability and reasoning level has improved since taking it. I stopped taking it for a week and I noticed my brain was getting foggy and I started having more thinking problems. So apparently it does work. I get it from Vitacost.com and its inexpensive as supplements go. I get the NSI brand that has Vit B6 included in it.

As for the question about anxiety levels and puberty I think even non-Aspie kids go through that. If she is having severe problems you might want to go to an OB/GYN and have them run a hormonal panel blood test on her and see if her female hormones are out of whack. That can totally make someone misbehave if their hormones are not normal. Just my two cents.

You can get some basic information on phospatidylserine from the PDR Health site. I have no idea whether it would help your daughter. Do a search, and make sure you get information not only from people selling the stuff.

don't know about the phosphy-whatever.....do know that anxiety levels do increase in puberty, unfortunately

You can get Phosphatidylserine from any drug store, at least in the united states. GNC sells it also. It isn't a medicine. It is a phospholipid(nutrient) needed for proper neuron function.

Phosphatidyl SERINE it was meeeeeeeeeeeeeeeeeeee!! ! HIYA FOLKS, I AM blown away by PS. IT IS BRILLIANT.

None of my children who were on Ritalin ( including myself) are on it anymore. PS is a non essential amino acid and crosses the blood barrier within 30mins..............YUP you heard right.

It chills out the most anxious kid, acts exactly same as Ritalin ONLY it is natural and it is safe! No hangover, no antipyschotics to go alongside it..............just gentle and healthy.

There are over 3000 published papers on it and Clinical Trials are underway in Israel. There is even a new Phosphatidyl Serine forum!

One of my children is Aspergers syndrome and it helps him too.

Chronic Fibromyalgia and Chronic Fatigue Syndrome sufferers have all reported amazing results.

A boy in London who was wheelchair bound is now walking as a result of Serine.

I have loads of information on it. Health shops do not often carry PS, it is the only one that is difficult to track down. I source it on net via vitacost.com. If anyone wants any information about PS just YELL!

We swear by the stuff, children at my sons school are being maintained ONLY by PS! It is nothing short of a miracle.

If it works you see it within half an hour, it is subtle and gentle and lasts about 4 or 5 hrs.

The maximum dose is 2gms a day and the only contraindications are if you are taking anti coagulation therapy such as Warfarin or Heparin.

The way it works is to inhibit Cortisol. We get flooded with Adrenaline and then Cortisol which knocks off our hippocampus so memory is impaired. With PS the Coritisol is in check and whooohooooo we can function!

Anyway do check it out. We use the Source Natural Phosphatidyl Serine 500mg Complex sofgels.

Happy to help in any way I can. But it is SAFE, HEALTHY AND GENTLE. Anyone in doubt can request a blood test to test levels prior to trying it. The blood test to ask for is PLASMA AMINO ACID testing.

A pot of PS costs about £14/$28

THANKS Jelibean,

I tried it, but at about half of what you now say is the maximum. It HELPS, but it is REALLY subtle, etc... BTW I AM on anticoagulation therapy. In fact, REAL high! I guess I should do some tests, but I didn't see any differences in INR(A measure of clotting time) yet, for warfarin. I am using GNCs PS product(tablet).

After hearing your statement about how it works, (I heard another, about how it works with Omega 3s and choline), I am anxious to really push it. That STRESS really kills me, and some say it basically destroys your hippocampus which is then repaired with glial cells. That is BAD, because current science believes the glial cells are the main source of raw materials to repair things, and that there is a limited supply.

Ok, I'm YELLING!...... Have Googled availability of PS locally and it appears to only be available in combination with other things eg. gingko. Is it best to get it on its own, or would it still work as part of a combination formula?

Also, what do you mean by NATURAL? Does this mean it is completely herbal and a dietary supplement, as opposed to being "on medication"? Is it addictive, or if you come off it, does it make symptoms worse? Do you have to take it regularly, or can you just use it on a needs basis? Basically, I am keen on anything that will de-stress my son's environment and particularly make school easier for him (and his teacher).

I think she means source natural is the brand.

It is NOT a medicine!

She said "PS is a non essential amino acid and crosses the blood barrier within 30mins"! TRANSLATION?

It is a NEEDED amino acid, but can be derived from other products, so it is not deemed "essential". "Essential" refers to nutrients that must be taken in order to be available. Non essential ARE needed, but other things can be used to make them. It is like you NEED carbohydrates BUT, if you don't get them, fat can be used and, failing that, muscle can be burned. Likewise, you NEED 20 amino acids, but only about 10 can't be made(And are thus ESSENTIAL). THEY are: arginine (required for kids, but not for adults), histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, and valine.

BTW Serine can be made from glycine. Glycine can be synthesized from acetic acid and some vitamins.

She said it crosses the blood brain barrier in 30 minutes. That means it takes about 30 minutes to start working.

You HAVE to have it, if you don't, you DIE! It is just that the body CAN produce some naturally from other things. So it isn't addictive, but you DO need to get it somehow.

Going off of it won't make things worse than they were before you went on. The brain is always trying to maintain a balance.

You CAN take it as desired. SHE said not over 2GMs. What I saw was closer to 1.5GMs, but still, I doubt there is a problem.

You ARE right though, it is confusing. They DO have "500mg", but they are 500mg capsules, and NOT PS:

http://store.sourcenaturalscatalog.com/sn1967.html

They are only 100mg PS. So 2GMs is really only 400mg PS. The other products there are complimentary though! The other 350mg is a soybean extract. That COULD be beneficial, but COULD lower a persons INR if they are on blood thinners.

BTW concerning your question about ginkobiloba? IT is a popular natural blood thinner and, I think, vasodilator. It prevents strokes, and increases blood flow to the brain. So it is ALSO a popular supplement for the brain. I haven't known anyone to overdose on it, so it is probably fine if you aren't taking another blood thinner.

BTW POSSIBLE Problems for ginko would be possibly more likely to get bruises, and possibly worse injuries if you say hit your head in a bad fall. That IS unlikely though, as it is generally not that much, and falls usually aren't that bad. If you are REALLY concerned, see a doctor. If you are in a high risk group for an aneurysm, for example, they could check your heart and/or brain. Of course, if you are ALREADY taking blood thinners, AVOID GINKO!

respect!! ! 2ukenkerl

Ok folks here goes PS!

Here is a link for a forum that deals with ONLY phosphatidyl serine, you will find all the academic papers and clinical trial links on here. Friendly lovely crowd who are very very happy to help in any way they can!

http://www.phpbbcity.com/forum/index.ph ... =psforadhd

There is even a youtube on it!

http://uk.youtube.com/watch?v=bFFdI2KKKSQ

A paper by Dr Tom De Koning

http://www.pubmedcentral.nih.gov/articl ... id=1223326

SERINE is a neurotransmitter and is derived from Bovine Brain! But obviously in todays climate we cannot expect or want our children to eat a cow brain! So now it is derived from SOYA.

Yes it is totally NATURAL. No it is NOT a chemical!

Yes it works IN A VERY SUBTLE way and you feel the effects within 30minutes. Depending on your metabolism and need it lasts for up to 12hrs although I need topping up every 4hrs!

I get it on the internet, we use Source Naturals although there are many brands available. I HAVE found though that once you get a brand that you like you tend to stick with it. The PS forum has a very very comprehensive list on there should you want to shop around.

PS is patented and the worldwide rights are already bought so it is very important obviously!

Anyone heard of an antibiotic called CYCLOSERINE?? It is very very expensive and it is the only antibiotic that I know helps with depression!???

Serine and PS is used for Alzheimers also, memory loss and general anxiety. I have a friend who reaches for a can of lager by 8am.............taking PS she felt no urge to drink, similarly I am a smoker but when I have PS on board my smoking reduces significantly

A friend of mine has a daughter with aspergers syndrome and FIBROMYLAGIA, it takes all the pain away in 20mins! Honestly


I could go on and on and on about PS, the miracles but I would bore you all to death. SUFFICE to say we find it BRILLIANT. Ritalin is a thing of the past!

Keep yelling questions and queries, that is what I am here for! If in doubt go and get some blood testing done, over here for a complete plasma amino acid screen it would cost about £100 so convert that into whatever currency you use!

Keep the questions coming, I will regularly check into the thread to see what is being said.

I order through a company called vitacost.com........NOOOoooo I don't work for them or know anyone that does, I only wish I DID! But they are reliable, quick and easy to use. I am in the UK and when ordered I get a parcel within 48hrs!!

GOOD LUCK EVERYONE AND YELL AWAY!! !! !

LINK to the brand we use...................NOT advertising promise, just informing.

http://www.vitacost.com/Source-Naturals ... ne-Complex

Bit more for you folks!

Am J Clin Nutr. 2008 May;87(5):1170-80.

Correlation between changes in blood fatty acid composition and visual sustained attention performance in children with inattention: effect of dietary n-3 fatty acids containing phospholipids.

Vaisman N, Kaysar N, Zaruk-Adasha Y, Pelled D, Brichon G, Zwingelstein G, Bodennec J.

Clinical Nutrition Unit, Tel Aviv Sourasky Medical Center, Tel-Aviv, Israel.
vaisman@tasmc.health.gov.il

BACKGROUND: Increasing evidence supports n-3 fatty acid (FA) supplementation for patients with psychiatric disorders, such as attention deficit hyperactivity disorder. However, the exact metabolic fate of dietary eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on different glyceride carriers remains unclear.

OBJECTIVE: We investigated whether conjugation of EPA and DHA to phospholipid (PL-n-3) or to triacylglycerol (fish oil; FO) affects their incorporation in blood compartments and influences executive functioning.

DESIGN: Children aged 8-13 y with impaired visual sustained attention performance received placebo, 250 mg/d EPA + DHA esterified to PL-n-3 (300 mg/d phosphatidylserine), or FO for 3 mo in a randomized double-blind manner. Main outcome measures included plasma and erythrocyte FA profile and continuous performance test results (Test of Variables of Attention; TOVA).

RESULTS: Sixty of the 83 children enrolled completed the interventions (n = 18-21 per group). There was an enrichment of EPA (1.5-2.2-fold), docosapentaenoic acid (DPA; 1.2-fold), and DHA (1.3-fold) in the PL fraction in the plasma of FO- and PL-n-3-fed children. In erythrocytes, only PL-n-3 resulted in a significant reduction (approximately 30%) of very-long-chain saturated FAs (C20-24) and in an increase (1.2- and 2.2-fold, respectively) in linoleic acid and DPA. Total TOVA
scores increased in the PL-n-3 (mean +/- SD: 3.35 +/- 1.86) and FO (1.72 +/-1.67) groups but not in the placebo group (-0.42 +/- 2.51) (PL-n-3 > FO >placebo; P < 0.001). A significant correlation between the alterations in FAs and increased TOVA scores mainly occurred in the PL-n-3 group.

CONCLUSION: Consumption of EPA+DHA esterified to different carriers had different effects on the incorporation of these FAs in blood fractions and on the visual sustained attention performance in children.

This trial was registered at clinicaltrials.gov as NCT00382616.

PMID: 18469236

I thought they might be using Sharp-PS Gold (PS+DHA), an Israeli product sold in the US as Country Life Sharp Thought, but that product doesn't seem to contain EPA.

One might compare the reported results to PS by itself in this 2006 abstract -- but in a Japanese population that likely consumes more fish than in most western countries.


AgroFOOD industry hi-tech
Anno 17 - No. 5 September/October 2006 16-20

Effect of phosphatidylserine administration on symptoms of attention-deficit/hyperactivity disorder in children

PURPOSE

To clarify whether the administration of phosphatidylserine
("PS") can improve the attention-deficit ("AD") and hyperactivity disorder ("HD") symptoms in children. with AD/HD.

STUDY DESIGN AND SUBJECTS

A pilot study in 15 AD/HD children 6 to 12 years old (including
6 suspected to have AD/HD) who had rarely received
medication before. These 15 children took 200 mg/day of PS
in a capsule every day for 2 months. The following items were
investigated at the start of study ("pre-study") and upon
completion of study ("post-study): 1) AD/HD symptoms
(inattention/hyperactivity and impulsiveness) based on DSM
IV diagnostic criteria, 2) learning disorders (hearing, speaking,
reading, writing, calculation, inference) based on learning
disorders ("LD") check list, 3) visual perception (figure
background perception task to find a prescribed form in the
sheet), 4) visual and auditory short-term memory and 5)
continuous performance test ("CPT").

RESULTS

After the intervention, (1) AD/HD symptoms were significantly
improved (p<0.01). Significant improvement was observed
both in the inattention and hyperactivity and impulsiveness
(p<0.01 and p<0.05 respectively) (3) visual perception was
also significantly improved (p<0.001). A tendency towards an
improvement was observed in (2) LD and (5) CPT (9 only
error) (p<0.10). However, no significant difference was
observed with regard to visual and auditory short-term
memory (4).

CONCLUSION

PS was shown to improve AD/HD symptoms as demonstrated
by the results of DSM-IV diagnostic criteria, visual perception
test, learning disorder checklist, and CPT. Further studies
using larger sample sizes are required to confirm the
significant beneficial results of PS on AD/HD of this pilot trial.



For further discussion of lipids see:

BMC Psychiatry. 2008 Apr 17;8 Suppl 1:S5.
Fatty acids and oxidative stress in psychiatric disorders.

BACKGROUND: The aim of this study was to determine whether there is published evidence for increased oxidative stress in neuropsychiatric disorders.

METHODS: A PubMed search was carried out using the MeSH search term 'oxidative stress' in conjunction with each of the DSM-IV-TR diagnostic categories of the American Psychiatric Association in order to identify potential studies.

RESULTS: There was published evidence of increased oxidative stress in the following DSM-IV-TR diagnostic categories: mental retardation; autistic disorder; Rett's disorder; attention-deficit hyperactivity disorder; delirium; dementia; amnestic disorders; alcohol-related disorders; amphetamine (or amphetamine-like)-related disorders; hallucinogen-related disorders; nicotine-related disorders; opioid-related disorders; schizophrenia and other psychotic disorders; mood disorders; anxiety
disorders; sexual dysfunctions; eating disorders; and sleep disorders.

CONCLUSION: Most psychiatric disorders are associated with increased oxidative stress. Patients suffering from that subgroup of these psychiatric disorders in which there is increased lipid peroxidation might therefore benefit from fatty acid supplementation (preferably with the inclusion of an antioxidant-rich diet) while patients suffering from all these psychiatric disorders might benefit from a change to a whole-food plant-based diet devoid of refined carbohydrate products.

PMCID: PMC2330073 -- With link to free full-text article



Finally, this fairly recent study which attempted to replicate the Oxford Durham Study with a more refined population analysis. The intervention was the commercial supplement "Equazen eye Q".

Responders seemed to fall into the ADHD-Inattentive and certain Developmental Disorders categories.

J Atten Disord. 2008 Apr 30 [Epub ahead of print]

Omega-3/Omega-6 Fatty Acids for Attention Deficit Hyperactivity Disorder: A Randomized Placebo-Controlled Trial in Children and Adolescents.

Johnson M, Ostlund S, Fransson G, Kadesjö B, Gillberg C.

Objective: The aim of the study was to assess omega 3/6 fatty acids (eye q) in attention deficit hyperactivity disorder (ADHD).

Method: The study included a randomized, 3-month, omega 3/6 placebo-controlled, one-way crossover trial with 75 children and adolescents (8-18 years), followed by 3 months with omega 3/6 for all. Investigator-rated ADHD Rating Scale-IV and Clinical Global Impression (CGI)
scale were outcome measures.

Results: A majority did not respond to omega 3/6 treatment. However, a subgroup of 26% responded with more than 25% reduction of ADHD symptoms and a drop of CGI scores to the near-normal range. After 6 months, 47% of all showed such improvement. Responders tended to have ADHD inattentive subtype and comorbid neurodevelopmental disorders.

Conclusion: A subgroup of children and adolescents with ADHD, characterized by inattention and associated neurodevelopmental disorders, treated with omega 3/6 fatty acids for 6 months
responded with meaningful reduction of ADHD symptoms.

PMID: 18448859

I was never aware of a patent on PS. If there IS a patent, companies are breaking a law that basically INVALIDATES the patent! HOWEVER, SHARP PS is a TRADEMARK! It is from enzymotec. SO, it seems Jelibean is talking about SHARP PS which is a VERY popular mixture, rather than PS alone.

http://www.enzymotec.com/Page.asp?cc=01030206

BTW they ALSO have ultra kosher versions, and one error came up IN HEBREW, so it is a jewish company.

PS IS good, and there is only a subtle difference. I just bought some from the vitamin shop, and IT says:

500mg Sharp PS which includes:
PSerine 100mg
PCholine 25mg
PEtanolamine 2.5mg
PInositol 1.5mg

All those items are ones that work synergistically with PS.

So there is an apparent 26mg discrepancy over the Source Naturals brand, and about 350mg on top of that.
It is likely water, glycerine, polyglycitol syrup and SOY products though.

I have been on the Sharp PS stuff at 2GMs for the past day. I think it HAS helped! Yesterday was a bad day, before I took it, so I think it might have helped a lot. I guess I will be your impartial guinea pig!

Whooohooo!! ! Well done! 2ukenkerl


Fantastic news, the difference is very subtle and sometimes it takes others to notice the difference. SO GLAD you think it is working...............I KNOW IT WORKS!! Whooohooo!

Come on everyone, jump on the bandwagon, for many including myself and my children + loads of others, psychostimualants are a thing of the PAST!!

I have researched PS for 2 yrs now so if there are any questions please do holla!

Yeah, my question is, if you've never bought it before, what would you advise is the best way to buy it eg. amounts, brand, etc. I went to the Vitacost link and thought, do I just by the first one sitting there, or others? My other complication is that I would be an overseas buyer (New Zealand), so am I better looking for it closer to home? (I have Googled it within New Zealand but not come up with any sellers).

Hiya annie2

Now NZ is one area that I am not familiar with BUT if you check out my post above you will see I have put in links to a specialised PS FORUM that was set up only a few months ago. I have a feeling we may have a NZ there.

But the USA delivery to here in the UK is 48hrs and is cheaper than if we were to buy it over the counter believe it or not! Even with shipping and import duty.

I have always used this brand and have found with other people that if they find a brand they like they tend to stick to it even if cheaper alternatives are available.

I started on PS Source Natural COMPLEX................which is 100mg Serine in 500mg SOFTGELS the rest is made up of phospholipids etc.

There are SOOOooo many available it is just your own preference.

The link for the brand we use is this one, although I would like to make it clear that we stumbled upon this one, liked it and stuck with it that is all! We were lucky to score a bullseye|!

http://www.vitacost.com/Source-Naturals ... ne-Complex . HOPE THAT HELPS! Anything else just feel free to holla! I COMPLETELY RATE THIS PRODUCT and would go as far as to say it has saved my life. The stress I was under was unbearable and I was on my last legs. Allostatic Load eh? Phew, thanks to PS GONE..........................!