It depends. When people are nice, it's easy to be around them, but often they are chaotic and unpredictable, meaning I get a random selection of responses and reactions which I don't like.
Some things bug me more than others. One thing that annoys me is when I get in a line that has a hold up. I tend to pick the slowest ones, the ones with the cashier who doesn't know how to do something, so she spends ten or fifteen minutes trying to figure out how to use a particular card the customer wants to pay with, or how to use a coupon or a money order or something.
Lines are the only time I actually get a chance to focus on the people around me. A few months ago, this woman was in line behind me at Wal Mart, talking on a cell phone. She was oblivious to all around her, having a completely innane conversation that consisted of her saying "I'm so ret*d" and "Don't be ret*d" about ten or twelve times to whomever she was talking to. It's not like I wanted to hear her, it's just that she was so unbelievably loud. Suddenly, she says "Gotta go" and I hear this loud whooping yell and this other woman comes up to her and gives her this hug. "It's so great to see you, I can't believe I bumped into you here, no time no see" and blah blah blah. It was like, so loud and so personal. I wondered if I really needed to be privy to such an intimate moment.
After I got through paying for my stuff, the woman was like, totally quiet and polite to the cashier, no longer talking on her cell phone or yelling at anyone. It was a Jekyll and Hyde moment. It frazzled my nerves, none the less.