Over 1,000 genes implicated in autism

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firemonkey
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28 Jan 2020, 7:29 am

(ANSA) - Turin, January 28 -

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Over 1,000 genes are implicated in autism, an international study including a Turin university and hospital and the university of Siena has shown.
The study ws conducted on some 35,000 people by the bodies, including Turin's Città della Salute Hospital.
The study was published in the journal Cell.
The data "is just the tip of the iceberg" said Alfredo Brusco of the Città della Salute Hospital.

http://www.ansa.it/english/news/science ... a050b.html

Fnord
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28 Jan 2020, 10:20 am

So maybe the severity of autism could be measured by how many of these genes express themselves ...?

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QuantumChemist
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28 Jan 2020, 10:33 am

It also might explain why the effects manifest differently in autistic conditions. Each combination of specific dominant genes could be responsible for a part of the spectrum. With a thousand variables to play with, it may take a long time to fully sort out.

Last edited by QuantumChemist on 28 Jan 2020, 10:36 am, edited 1 time in total.

Fnord
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28 Jan 2020, 10:36 am

QuantumChemist wrote:

It also might explain why it manifests differently in autistic conditions. Each combination of genes could be responsible for a part of the spectrum. With a thousand variables to play with, it may take a long time to fully sort out.

If you take the state of each gene as either "Active/On" or "Inactive/Off", then the number of combinations could be somewhere around 2 raised to its 1000th power (2^1000).

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pyrrhicwren
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28 Jan 2020, 10:40 am

Fnord wrote:

So maybe the severity of autism could be measured by how many of these genes express themselves ...?

Epigenetics?????

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QuantumChemist
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28 Jan 2020, 10:41 am

Fnord wrote:

QuantumChemist wrote:

[color=black]If you take the state of each gene as either "Active/On" or "Inactive/Off", then the number of combinations could be somewhere around 2 raised to its 1000th power (2^1000).

Even with the most powerful super computers working on it, the study might not be finished in our lifetimes.

firemonkey
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28 Jan 2020, 10:52 am

Fnord wrote:

So maybe the severity of autism could be measured by how many of these genes express themselves ...?

That sounds plausible .

firemonkey
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28 Jan 2020, 10:55 am

Fnord wrote:

QuantumChemist wrote:

If you take the state of each gene as either "Active/On" or "Inactive/Off", then the number of combinations could be somewhere around 2 raised to its 1000th power (2^1000).

My mind boggles at the number of combinations!! Would there be certain genes that would be expected to occur with each other ?

firemonkey
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28 Jan 2020, 10:57 am

QuantumChemist wrote:

Fnord wrote:

QuantumChemist wrote:

[color=black]If you take the state of each gene as either "Active/On" or "Inactive/Off", then the number of combinations could be somewhere around 2 raised to its 1000th power (2^1000).

Even with the most powerful super computers working on it, the study might not be finished in our lifetimes.

Something the World community grid should get involved in?

pyrrhicwren
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28 Jan 2020, 11:11 am

firemonkey wrote:

QuantumChemist wrote:

Fnord wrote:

QuantumChemist wrote:

[color=black]If you take the state of each gene as either "Active/On" or "Inactive/Off", then the number of combinations could be somewhere around 2 raised to its 1000th power (2^1000).

Even with the most powerful super computers working on it, the study might not be finished in our lifetimes.

Something the World community grid should get involved in?

I wonder what would process that amount of combinations and spot patterns; harnessing the world's computers' processing power, paralelled super computers, or multiple functional high q-bit quantum computers?

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kraftiekortie
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28 Jan 2020, 11:19 am

I'm not surprised at this at all.

Autism has many causes, and many presentations.

It's just common sense, really, to believe that autism is not just one monolithic disorder.

This is why there will never be a "cure." And why there will never occur the abortion of children who are found to have autism.

Marybird
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28 Jan 2020, 11:55 am

I'm sure they mean pathogenic variation or mutation in the coding sequence of any one of those genes could possibly lead to autism.

kraftiekortie
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28 Jan 2020, 12:11 pm

I believe there are certain genes that could cause a predisposition towards autism—without autism being an inevitable result.

Karamazov
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28 Jan 2020, 2:39 pm

kraftiekortie wrote:

I believe there are certain genes that could cause a predisposition towards autism—without autism being an inevitable result.

Sounds credible to me: I’d also add that I doubt all the 1000+ genetic alleles are present in all of us. Suspect it’s more likely we each have a unique combination of actives and inactives.
But that’s speculation of course.

naturalplastic
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29 Jan 2020, 5:37 pm

The entire human genome consists of only 30 thousand genes.

So this "discovery" is overkill. If one in thirty of every human gene can correlate with autism then normal variations in human genes (and in gene expression) would cause everyone to be autistic. If gene 13 didn't get ya, then gene number 887 would. This discovery is kinda meaningless.

Unless maybe you are arguing that it IS meaningful because it shows that its turns the question on it's head, and now we need to find what gene STOPS folks from being autistic , since there are so many ways for genes to cause us to be autistic.

firemonkey
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29 Jan 2020, 5:54 pm

Wouldn't differences in SNPs also come into play ?

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