Chance that a chld will have AS

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What is the chance that a child of a person with AS will also have AS?

ok im trying to answer this easily without picking apart your question too much, sorry it is a habit.

i think if a parent has it, a child has it.


and that is the end of the answer to the question. the child.....WILL in my opinion HAVE AS.


however , if a parent has it and a child has it, the question should be, what is the chances of the child being diagnosed with AS?

and the answer is: 9 times more if the child is male.

point is?

there is no objective test to diagnose AS

there is no way of knowing if a child will develop AS from an AS parent.

however i will end with this.....i am AS ( i dont have it, its not something im afflicted with, it is something i am)
My son is AS]my father is AS.

so thr force is strong in my family.

In terms of genetics, I think it would make sense to equate it to all genetic qualities...depending on which traits both parents share. I have one aspie child and one who is not. One like him and one like me, in almost every way, mannerisms, personality, physical traits, coloring...almost everything.

The real question is:

Is there anyone in both sides of the family that has any form of autism of any level? If so, these genes WILL be carried by everyone down the line. They just remain dormant. The chances then are the same as determining the gender of the baby.

Why do you think doctors nearly always ask "Is there a history of <X> in the family?"

Until we understand the cause/s of AS better, we cannot know.

In the most simple case, a single gene for which there are only two alleles would determine the presence or not of AS, and the AS allele would be dominate. In that case, and barring any other complicating factor, a child of a parent with AS would have a 50% chance of inheriting the dominate AS allele and therefore AS. Any child who did not develop AS in this scenario, would also not inherit the allele for AS and so could not 'pass it down' to their descendants.

Even in an instance where there is still only one allele that causes AS, and one that does not, but the AS allele is recessive, things get more complicated. If there is only one parent with AS, their child/ren have 100% chance of inheriting a copy of the AS allele, however, they will only have AS if their other parent has a copy of the allele and pases it on to them. If the other parent has a copy of the allele, the child has a 50% chance of inheriting it and AS. If the other parent does not have an AS allele, the child would have a 0% chance of having AS, even though they would have a 100% chance of inheriting a single AS allele, and a 50% chance of passing it on to any of their off-spring.

Things get more complicated if there are multiple genes involved, and especially if the genes are spread across multiple chromosomes. Even more complexity is involved if more than one set of causal factors produce the 'trait/characteristic cluster' described by 'AS'.

I can't speak for others, but it appears that I have it. It also appears that I passed it on to both my kids. All 3 of us have our far share of quirkiness. I would think genetically it would be 1 in 4 that would have it. At least, that's the normal ratio for things like blue eyes....assuming that AS works in a similar manner. But since there isn't much known about it yet, it could have some other way of manifesting.

You can't use one-gene things like blue eyes to determine likelihood of AS because AS has multiple genes involved.

My family:

Mother: Asperger's
Father #1: Autistic
Father #2: NT

Child 1, of father #1: Asperger's
Child 2, of father #1: NT
Child 3, of father #3: Asperger's

See? Not that simple. You can have two autistic parents and and NT child, and you can have an autistic parent with an NT parent and have an autistic child anyway.

More proof that simple Mendelian genetics doesn't work with autism:

Odds of autistic child: 1:150.
Odds given a sibling has ASD: 1:20
Odds given identical twin has ASD: 19 in 20.

Siblings share 50% of DNA
Twins share 100% of DNA

Having only half the genes of someone who has autism is only 1/19th as powerful as having all of the genes the same as someone with autism
All found possible genetic markers seem to be correlated only with very small percentages of autism cases-- 1-3% (excluding Rett's)

Probably true:
Not all autistic people have all the possible genetic risk factors for autism
Many NTs have genes for autism despite not being autistic
Genetic risk factors for autism are very numerous and most autistics do not share the same ones
A certain 'load' is necessary to pass diagnostic threshold

Complicated.

Have not yet heard of a survey of autistic parents. Possibly has not been done because it would almost certainly be worthless: Adults are much more likely to be diagnosed with autism if their children were diagnosed first.

...other than studying a bunch of autistic couples to see whether they pass it on, and at what rate...

But this is problematic .

The Roulette of AS topic

My three children are NT. Very NT.

My brother is Tourettes. My sister Attention deficit. But their personalities are NT.

One grandfather had Aspie traits as did a great-grandfather. Some more distant relatives were quirky.

You just can never know for sure.

This is what I wonder if my AS partner and I have children (I have AS too).

He already has three children; one with AS, one with autism (both of which from the same mother, who recently got diagnosed with AS), and one who may have AS but we don't get to see her.

I don't know what could happen. It's probable that the child would "have something". I don't even know if I want to put a child through what I went through. Though I suppose it would be different because the child would be surrounded by those who are alike and in the know.

I am no expert on genetics. I am still learning about Aspergers & how it manifests itself. So if I do make a mistake about how it is passed on, please forgive me! I am adopted & have little knowledge about my biological parents. If Aspergers is genetic, then it means that at least on of my parents had it in order for me to pass it on to my children. My thoughts are based on personal observations & memories. Nothing is written in stone for me regarding this subject. I am curious about it, & doing my best to learn as much as I can so I can better help my 2 kids so they can get along & adapt as best they can.

For Autism, I think the latest figure is a 50% chance of it being passed on. They base it on fairly broad assumptions however, i.e., females can inherit the disorder, but the symptoms don't always manifest (the 5 to 1 male/female ratio), and they can pass it on to their children in the 50/50 manner, and if it's a boy, the boy will have the full disorder.